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Caffeine is classified by the US Food and Drug Administration as "generally recognized as safe" (GRAS).Toxic doses, over 10 grams per day for an adult, are much higher than typical doses of under 500 milligrams per day.A systematic review, analyzing the results of observational studies, suggests that women who consume large amounts of caffeine (greater than 300 mg/day) prior to becoming pregnant may have a higher risk of experiencing pregnancy loss.However, acute ingestion of caffeine in large doses (at least 250–300 mg, equivalent to the amount found in 2–3 cups of coffee or 5–8 cups of tea) results in a short-term stimulation of urine output in individuals who have been deprived of caffeine for a period of days or weeks.Caffeine also stimulates certain portions of the autonomic nervous system.
Thus it requires roughly 50–100 ordinary cups of coffee to reach a lethal dose.
Beverages containing caffeine are ingested to relieve or prevent drowsiness and to improve performance.
To make these drinks, caffeine is extracted by steeping the plant product in water, a process called infusion.
Withdrawal can cause mild to clinically significant distress or impairment in daily functioning.
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The frequency at which this occurs is self reported at 11%, but in lab tests only half of the people who report withdrawal actually experience it, casting doubt on many claims of dependence.
It is found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia and helps to protect them against predator insects and to prevent germination of nearby seeds.
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