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05-Jan-2020 22:16

There are currently around 10-15 people with the syndrome in Sweden (2012). An English study suggests an incidence of 1 per 500,000 newborns.

In 25 per cent of cases the child will not have the disease and will not be a carrier of the mutated gene.

Mucopolysaccharide depositions in the meninges (the membranes that cover the brain and spinal cord) prevent normal drainage of cerebrospinal fluid, thereby leading to the development of hydrocephalus.

The abdomen protrudes owing to enlarged liver and spleen, and inguinal (groin) or umbilical hernias are common.

Lysosomes contain enzymes, proteins that contribute to chemical reactions without themselves undergoing any permanent change, and whose function is to digest and break down various substances.

Hurler, Hurler-Scheie and Scheie syndromes are characterized by alpha-L-iduronidase deficiency, which results in the build-up of undigested mucopolysaccharides in the cells.Publication date: 2012-09-20 Version: 1.1 Hurler syndrome (MPS IH), Hurler-Scheie syndrome (MPS 1 H/S), and Scheie syndrome (MPS I S) are inherited conditions that belong to a group of disorders known as the mucopolysaccharidoses (MPS syndromes).

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